Microlab NIMBUS Automated Liquid Handling Systems by Hamilton Robotics

• NIMBUS4 Base Platforms: Open, Enclosed, Extended Enclosed and Large Extended Enclosed

• NIMBUS94 Base Platforms: Open, Extended Enclosed and Large Extended Enclosed

• NIMBUS384 Base Platforms: Open, Extended Enclosed and Large Extended Enclosed

• Features:

• Up to four independent liquid channels (NIMBUS4)

• Fast plate-based pipetting with CO-RE 96 MPH or the CO-RE 384 MPH (NIMBUS96 and NIMBUS384)

• Available locking feature on enclosed models minimizes environmental contamination

• Extension plate on left or right side of extended models provides four additional locations for Hamilton stackers, pedestals, Hamilton Heater Shaker and small third-party devices

• Door locks automatically when system is running, pause/park button, attachable waste station for used tips and NTRs, communications and control panel

• Movement and status indicators provide visual cues to the operational status

• CO-RE Paddles enable transport of plates or tips across deck without a dedicated labware gripper

• Compressed O-Ring Expansion (CO-RE) with robust lock-and-key attaches disposable tips, needles or transportation tools to pipetting channels without the vertical force eliminates stress and improves overall system reliability, speed, positional accuracy and dexterity

• Air Displacement Pipetting: analogous to hand pipetting and the benefits of liquid-free pipetting, reduces the risk of contamination, provides accuracy and precision from sub-microliter to large volumes (>1 mL), pipetting range from 0.5 μL to 1000 μL using the 1000 μL pipetting channel

• Liquid Level Detection (LLD): capacitatiive (cLLD) and pressure-based (pLLD)

• Monitor Air Displacement (MAD) provides real-time detection of clots or empty wells during aspiration

• Total Aspiration and Dispense Monitoring (TADM) real-time verification of sample transfer with traceable digital audit trail (only on NIMBUS4)

• Anti-Droplet Control (ADC) reduces deck contamination by preventing inadvertent dripping from channels with real-time detection and reaction to pressure changes for each pipetting channel (only on NIMBUS4)

• INSTINCT and VENUS Software:

• Instinct Software for basic programming:

• User-friendly with graphical user interface, labware library, quick selection of most used labware, liquid class tuner, 3D viewing

• Automated deck layouts and automated tip tracking

• Auto-transports labware to destination or waste locations

• Dedicated Wizard designed for basic tasks and used pipetting routines such as: serial dilutions, reagent additions, plate replications, tube to plate, PCR setup, SPE

• VENUS Software for advanced programming:

• Enables creation or modification of complex methods from scratch with a range of utilities for: worklist importing/exporting, error handling and recovery, LMS adaptation, database/server controls, scheduling, integrated third-party device control

• 21 CFT Part II compliant

• Audit trails, user group defined security functionality and checksum system for file fidelity

• Automated Applications:

• ADMET assays, CE analysis setup, Cell assays and feeding, Cloning assays, DNA/RNA extraction and purification, ELISA preparation and processing, Liquid-liquid extraction, MALDI target spotting, Microarray sample preparation, PCR setup and purification, Post-PCR cleanup, Protein purification and digestion, Sample normalization, Sample pooling, Sequencing assays, Solid phase extraction, Solubility assays

• Integrated Options (specify when ordering):

• Versatile Deck Options satisfies different assays:

• 4 x 5 high density deck up to 20 SLAS ANSI options, allows for tips and plate stacking, integrates with heaters, shakers and chillers, tube and plate barcode reading (NIMBUS4 only)

• 3 x 4 with 12 positions used for all standard SLAS ANSI labware ((in NIMBUS4 only)

• 9 + 2 for 11 SLAS ANSI positions, 9 positions for standard SLAS ANSI labware, 2 positions for tip stacking, plate stacking, small third-party integrations and for labware taller than 118 mm, and plate barcode reading

• SHIFT-N-SCAN with 8 SLAS ANSI plate and trough positions, 3 barcoded tube locations (up to 96 tubes, and plate barcode reading (NIMBUS4 only)

• Barcode Scanner reads 1D barcodes microplates presented by the optional Labware Gripper

• Labware gripper arm with 270° rotation allows seamless handoffs to integrated devices of single or stacked microplates, lids, and Hamilton’s Nested Tip Racks (NTR)

• CO-RE Paddles (only on NIMBUS4) cost-effective on-deck transport of labware (available for 1000 μL and 5 mL channels)

• MPE: compact device automates positive pressure solid phase extraction (SPE) and evaporation, applies up to 100 psi of pressure with dual circuit even-flow manifold

• Clean Air Protection System (CAP): cost-effective solution for sterile airflow

• CO-RE Lid Tool: picks up microplates and petri dish lids

• Hamilton Heater Shaker: on-deck orbital shaking and heating up to 100°C and accommodates various SLAS ANSI plates, from microliter to deep-well plates, and tube

• Plate Tilt Module, Fill Module, and NIMBUS Vacuum Station (NVS)

• Accessories: labware pedestals, labware adapters (speak to our product specialist for details)

• Consumables: Sterile and non-sterile CO-RE tips from 10μL to 5,000 μL, nested tip racks

• Specifications:

• Power Supply: UL/CSA/CE approved universal power supply with IEC connection

• NIMBUS CSA Certification: Installation Category – II; Pollution degree – 2

• Operating Temperature: 15° to 35 °C (59° to 95 °F)

• Relative Humidity: 30% to 85% R.H. non-condensing

• Altitude: 0 – 2000 m above sea level

• Storage Temperature: -20 °C (-4.0 °F) @ 10% humidity to 70 °C (158 °F) @ 90% humidity non-condensing